{"entity":{"id":"hypo-rt-pc","kind":"trial","name":"HYPO-RT-PC","aka":[],"tldr":"The Scandinavian HYPO-RT-PC trial showed that seven large radiotherapy doses control intermediate- to high-risk prostate cancer as well as 39 conventional ones, with similar late side effects.","summary":"HYPO-RT-PC randomised 1,200 men with intermediate- or high-risk prostate cancer, without hormone therapy, to ultra-hypofractionated radiotherapy (42.7 Gy in seven fractions, three per week) or conventional fractionation (78 Gy in 39). Five-year failure-free survival was 84 percent in both arms, meeting non-inferiority; acute urinary toxicity was higher with the short schedule but late toxicity was similar (Widmark and colleagues, Lancet 2019).","status":"positive","asOf":"2026-09-16","links":[{"label":"ISRCTN45905321","url":"https://www.isrctn.com/ISRCTN45905321"},{"label":"Lancet 2019","url":"https://doi.org/10.1016/S0140-6736(19)31131-6"}],"tags":["radiation-wave2"],"related":[],"cancers":["prostate"],"sections":[],"technologies":["hypofractionated-radiotherapy","sbrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"phase":"3","setting":"Intermediate- and high-risk prostate cancer: 42.7 Gy in seven fractions over two and a half weeks versus 78 Gy in 39 fractions","sponsor":"Umea University (Sweden)","result":"5-year failure-free survival 84% in both arms, non-inferior.","yearReported":2019,"enrolled":1200,"outcomes":[{"endpoint":"Failure-free survival at 5 years","primary":true,"unit":"%","arms":[{"name":"42.7 Gy in 7 fractions","n":598,"value":84},{"name":"78 Gy in 39 fractions","n":602,"value":84}]}]},"route":"/trials/hypo-rt-pc/","neighbours":{"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"hypofractionated-radiotherapy","kind":"technology","name":"Hypofractionated radiotherapy","route":"/technologies/hypofractionated-radiotherapy/"},{"id":"sbrt","kind":"technology","name":"SBRT / SABR (stereotactic radiotherapy)","route":"/technologies/sbrt/"}]}}