{"entity":{"id":"ice-compress-swog","kind":"trial","name":"ICE COMPRESS (SWOG, cooling or compression of limbs to prevent neuropathy)","aka":["ICE COMPRESS","Comparing Cooling and/or Compression Approaches of Limbs for Prevention of Chemotherapy-Induced Peripheral Neuropathy"],"tldr":"A large US trial testing whether cooling, squeezing or both protect the nerves in the hands and feet during chemotherapy. It is the trial expected to settle a question small studies have left open.","summary":"ICE COMPRESS is a SWOG phase 3 trial with an estimated 777 participants comparing cryocompression therapy with pneumatic compression therapy of the limbs to prevent chemotherapy-induced peripheral neuropathy, with quality-of-life and biospecimen measures. ClinicalTrials.gov gives an estimated primary completion in August 2030.","status":"recruiting","asOf":"2026-11-04","links":[{"label":"ClinicalTrials.gov NCT05642611","url":"https://clinicaltrials.gov/study/NCT05642611"}],"tags":["machines-wave3"],"related":[],"cancers":[],"sections":[],"technologies":["limb-cryocompression-devices","frozen-gloves-compression-taxane"],"targets":[],"drugs":[],"companies":["swog"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo machines inventory (openFDA, accessdata.fda.gov, ClinicalTrials.gov v2, Europe PMC, maker pages)","editedOn":"2026-11-04"},"nct":"NCT05642611","phase":"3","setting":"People with solid tumours starting neuropathy-causing chemotherapy, randomised between cryocompression and pneumatic compression approaches to the hands and feet","sponsor":"SWOG Cancer Research Network","started":"2023-06-06","startedType":"actual","enrolled":777,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/ice-compress-swog/","neighbours":{"technology":[{"id":"frozen-gloves-compression-taxane","kind":"technology","name":"Frozen gloves, socks and compression for taxane nail and nerve damage","route":"/technologies/frozen-gloves-compression-taxane/"},{"id":"limb-cryocompression-devices","kind":"technology","name":"Limb cryocompression devices for chemotherapy nerve damage (Paxman Neuropathy System, Hilotherm ChemoCare)","route":"/technologies/limb-cryocompression-devices/"}],"company":[{"id":"swog","kind":"company","name":"SWOG Cancer Research Network","route":"/companies/swog/"}],"roadmap":[{"id":"chemo-chair-comfort-devices-roadmap","kind":"roadmap","name":"Comfort devices at the chemotherapy chair: scalp cooling, cold caps, limb cryocompression and infusion chairs","route":"/roadmaps/chemo-chair-comfort-devices-roadmap/"}],"idea":[{"id":"idea-mach-cold-or-compression-by-adherence","kind":"idea","name":"Choose cold or compression for neuropathy by what patients can keep on","route":"/ideas/idea-mach-cold-or-compression-by-adherence/"}]}}