{"entity":{"id":"idera-pharmaceuticals","kind":"company","name":"Idera Pharmaceuticals","aka":["Idera Pharmaceuticals, Inc.","Idera","Aceragen"],"tldr":"Idera was a Cambridge biotech whose injected TLR9 agonist tilsotolimod, given into tumours with ipilimumab, failed a phase 3 trial in anti-PD-1-refractory melanoma in 2021.","summary":"Idera Pharmaceuticals, founded in 1989 and based in Cambridge, Massachusetts, developed oligonucleotide Toll-like receptor agonists. Its intratumoural TLR9 agonist tilsotolimod was tested with ipilimumab in the phase 3 ILLUMINATE-301 trial in melanoma that had progressed on anti-PD-1 therapy and did not improve response or survival. The company merged with Aceragen in 2022 and later wound down. Its trials remain on ClinicalTrials.gov under Idera as lead sponsor.","asOf":"2026-09-11","links":[{"label":"Official website","url":"http://www.iderapharma.com"},{"label":"ClinicalTrials.gov: trials led by Idera Pharmaceuticals, Inc.","url":"https://clinicaltrials.gov/search?lead=Idera%20Pharmaceuticals%2C%20Inc."},{"label":"Wikidata","url":"https://www.wikidata.org/wiki/Q30296240"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["melanoma"],"sections":[],"technologies":["in-situ-vaccination"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["pivotal-trial","clinical-trial"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Cambridge, MA","country":"US","companyType":"biotech","website":"http://www.iderapharma.com","founded":1989,"stage":"defunct","investors":[],"funding":[]},"route":"/companies/idera-pharmaceuticals/","neighbours":{"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"technology":[{"id":"in-situ-vaccination","kind":"technology","name":"In situ vaccination","route":"/technologies/in-situ-vaccination/"}],"term":[{"id":"clinical-trial","kind":"term","name":"Clinical trial","route":"/terms/clinical-trial/"},{"id":"pivotal-trial","kind":"term","name":"Pivotal (registrational) trial","route":"/terms/pivotal-trial/"}]}}