{"entity":{"id":"ikbkb","kind":"target","name":"IKBKB","aka":["inhibitor of nuclear factor kappa B kinase subunit beta","Inhibitor of nuclear factor kappa-B kinase subunit beta","IKK2","NFKBIKB","IKK-beta"],"tldr":"IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target and an oncogene driver, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma, Skin cancer, Breast cancer and 2 more.","summary":"Serine kinase that plays an essential role in the NF-kappa-B signalling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues.\n\nOpen Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.90, clinical 0.08). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Plasma Cell Myeloma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5960","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5960"},{"label":"UniProt O14920","url":"https://www.uniprot.org/uniprotkb/O14920/entry"},{"label":"NCBI Gene 3551","url":"https://www.ncbi.nlm.nih.gov/gene/3551"},{"label":"Ensembl ENSG00000104365","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104365"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["multiple-myeloma","skin-cancer","breast-cancer","lung-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.12; IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IKBKB","role":["drug-target","oncogene-driver"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5960","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5960","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O14920","url":"https://www.uniprot.org/uniprotkb/O14920/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000104365","url":"https://platform.opentargets.org/target/ENSG00000104365/associations","note":"association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: melanoma 0.57, skin cancer 0.56, breast cancer 0.54, lung cancer 0.53 (GraphQL API, CC0)"},{"label":"IntOGen IKBKB","url":"https://www.intogen.org/search?gene=IKBKB","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:5960","ensembl":"ENSG00000104365","uniprot":"O14920","entrez":"3551","biology":"Serine kinase that plays an essential role in the NF-kappa-B signalling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signalling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. Location: Cytoplasm; Nucleus; Membrane raft (UniProt). Locus 8p11.21 (HGNC).","whereFound":["Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)","Melanoma: Open Targets association 0.57 with melanoma (MONDO_0005105)"],"targetClass":"kinase","prevalence":[]},"route":"/targets/ikbkb/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}