{"entity":{"id":"il2rb","kind":"target","name":"IL2RB","aka":["interleukin 2 receptor subunit beta","Interleukin-2 receptor subunit beta","CD122","IL15RB"],"tldr":"IL2RB (Interleukin-2 receptor subunit beta) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Leukaemia, Renal cell carcinoma and 3 more.","summary":"Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.84, animal model 0.52, genetic association 0.00, clinical 0.96). In OnCo, 1 product record names it (Bempegaldesleukin).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6009","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6009"},{"label":"UniProt P14784","url":"https://www.uniprot.org/uniprotkb/P14784/entry"},{"label":"NCBI Gene 3560","url":"https://www.ncbi.nlm.nih.gov/gene/3560"},{"label":"Ensembl ENSG00000100385","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100385"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","leukaemia","rcc","non-hodgkin-lymphoma","cutaneous-t-cell-lymphoma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":["bempegaldesleukin"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IL2RB","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6009","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6009","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P14784","url":"https://www.uniprot.org/uniprotkb/P14784/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000100385","url":"https://platform.opentargets.org/target/ENSG00000100385/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: renal cell carcinoma 0.52, melanoma 0.55, non-Hodgkin lymphoma 0.51, skin cancer 0.56, leukaemia 0.53, primary cutaneous T-cell non-Hodgkin lymphoma 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:6009","ensembl":"ENSG00000100385","uniprot":"P14784","entrez":"3560","biology":"Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. Location: Cell membrane (UniProt). Locus 22q12.3 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Leukaemia: Open Targets association 0.53 with leukaemia (MONDO_0005059)","Renal cell carcinoma: Open Targets association 0.52 with renal cell carcinoma (MONDO_0005086)","Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)","Cutaneous T-cell lymphoma: Open Targets association 0.55 with primary cutaneous T-cell non-Hodgkin lymphoma (MONDO_0000607)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)"],"targetClass":"other","prevalence":[]},"route":"/targets/il2rb/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cutaneous-t-cell-lymphoma","kind":"cancer","name":"Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome)","route":"/cancers/cutaneous-t-cell-lymphoma/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"drug":[{"id":"bempegaldesleukin","kind":"drug","name":"Bempegaldesleukin","route":"/drugs/bempegaldesleukin/"}]}}