{"entity":{"id":"il2rg","kind":"target","name":"IL2RG","aka":["interleukin 2 receptor subunit gamma","Cytokine receptor common subunit gamma","CD132","SCIDX1","IMD4"],"tldr":"IL2RG (Cytokine receptor common subunit gamma) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Renal cell carcinoma, Leukaemia and 3 more.","summary":"Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.90, animal model 0.54, genetic association 0.00, clinical 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6010","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6010"},{"label":"UniProt P31785","url":"https://www.uniprot.org/uniprotkb/P31785/entry"},{"label":"NCBI Gene 3561","url":"https://www.ncbi.nlm.nih.gov/gene/3561"},{"label":"Ensembl ENSG00000147168","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147168"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","rcc","leukaemia","non-hodgkin-lymphoma","melanoma","cutaneous-t-cell-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IL2RG","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6010","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6010","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31785","url":"https://www.uniprot.org/uniprotkb/P31785/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000147168","url":"https://platform.opentargets.org/target/ENSG00000147168/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: renal cell carcinoma 0.54, melanoma 0.55, non-Hodgkin lymphoma 0.51, skin cancer 0.56, leukaemia 0.54, primary cutaneous T-cell non-Hodgkin lymphoma 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:6010","ensembl":"ENSG00000147168","uniprot":"P31785","entrez":"3561","biology":"Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. Location: Cell membrane; Cell surface (UniProt). Locus Xq13.1 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Renal cell carcinoma: Open Targets association 0.54 with renal cell carcinoma (MONDO_0005086)","Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)","Cutaneous T-cell lymphoma: Open Targets association 0.55 with primary cutaneous T-cell non-Hodgkin lymphoma (MONDO_0000607)"],"targetClass":"other","prevalence":[]},"route":"/targets/il2rg/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cutaneous-t-cell-lymphoma","kind":"cancer","name":"Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome)","route":"/cancers/cutaneous-t-cell-lymphoma/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}