{"entity":{"id":"il6st","kind":"target","name":"IL6ST","aka":["interleukin 6 cytokine family signal transducer","Interleukin-6 receptor subunit beta","GP130","CD130","sGP130","IL-6RB"],"tldr":"IL6ST (Interleukin-6 receptor subunit beta) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Prostate cancer, Colorectal cancer and 1 more.","summary":"Functions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric complex CRLF1-CLCF1. Engages site 2 of CNTF, CLCF1, LIF, and IL-6, and site 3 of IL27 and IL6. Initiates signal transmission through three mechanisms.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.31, literature 0.95, genetic association 0.00, somatic mutation 0.85, animal model 0.57). IntOGen calls it a driver in 4 cohorts (2 activating, 1 loss-of-function), covering Hepatocellular Carcinoma, Prostate Adenocarcinoma, Prostate.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6021","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6021"},{"label":"UniProt P40189","url":"https://www.uniprot.org/uniprotkb/P40189/entry"},{"label":"NCBI Gene 3572","url":"https://www.ncbi.nlm.nih.gov/gene/3572"},{"label":"Ensembl ENSG00000134352","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000134352"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["hcc","prostate","colorectal","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IL6ST","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6021","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6021","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P40189","url":"https://www.uniprot.org/uniprotkb/P40189/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000134352","url":"https://platform.opentargets.org/target/ENSG00000134352/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.55, skin cancer 0.52 (GraphQL API, CC0)"},{"label":"IntOGen IL6ST","url":"https://www.intogen.org/search?gene=IL6ST","note":"driver in 4 cohorts (Act 2, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6021","ensembl":"ENSG00000134352","uniprot":"P40189","entrez":"3572","biology":"Functions as a shared signal-transducing subunit not only for IL6 but also for other cytokine receptor complexes, including IL6, LIF, OSM, CNTF, IL11, CTF1, BSF3, MT-RNR2/humanin, CLCF1 and the heterodimeric complex CRLF1-CLCF1. Engages site 2 of CNTF, CLCF1, LIF, and IL-6, and site 3 of IL27 and IL6. Initiates signal transmission through three mechanisms. Binding of cytokines, such as IL6 or IL11 to the alpha-chains of their specific cell surface receptor triggers homodimerisation of IL6ST/gp130. In contrast, binding of other IL-6 family cytokines can result in the formation of a IL6ST/gp130 heterodimer with another signal-transducing receptor, such as LIFR or OSMR. Moreover, binding of CNTF or CLCF1 or the heterodimeric complex CRLF1-CLCF1 or MT-RNR2/humanin to the non-signalling receptor CNTFR induces heterodimerisation of the IL6ST/gp130 with LIFR or IL27RA/WSX1 (in the case of MT-RNR2/humanin). Location: Cell membrane; Secreted (UniProt). Locus 5q11.2 (HGNC).","whereFound":["Hepatocellular carcinoma: IntOGen driver in 2 cohorts (HCC)","Prostate cancer: IntOGen driver in 2 cohorts (PRAD, PROSTATE)","Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)","Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/il6st/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}