{"entity":{"id":"impact-bcc","kind":"trial","name":"IMPACT (cemiplimab in advanced basal cell carcinoma)","aka":["ISRCTN10511385"],"tldr":"The British trial testing whether the immunotherapy that works for advanced squamous cell carcinoma also works, first line, for the advanced basal cell carcinomas NICE refused to fund a hedgehog inhibitor for.","summary":"Advanced basal cell carcinoma is the gap in the English funding table: NICE refused vismodegib in TA489, sonidegib has never been appraised at all, and what NHS England does fund through the national list is vismodegib for multiple operable lesions rather than for locally advanced disease. IMPACT asks whether first-line cemiplimab, already funded for advanced cutaneous squamous cell carcinoma under TA802, is an answer for this group. It is sponsored by University Hospitals Bristol and Weston with a target of 41 participants and a registered end date of 30 April 2029.","status":"recruiting","asOf":"2026-09-25","links":[{"label":"ISRCTN10511385","url":"https://www.isrctn.com/ISRCTN10511385"}],"tags":["uk","skin","basal-cell-carcinoma","recruiting"],"related":[],"cancers":["basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":["cemiplimab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"ISRCTN10511385","phase":"2","setting":"UK phase 2 trial of three-weekly cemiplimab as first-line treatment for locally advanced basal cell carcinoma; registered end date 30 April 2029","sponsor":"University Hospitals Bristol and Weston NHS Foundation Trust","enrolled":41,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/impact-bcc/","neighbours":{"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"drug":[{"id":"cemiplimab","kind":"drug","name":"Cemiplimab","route":"/drugs/cemiplimab/"}]}}