{"entity":{"id":"impdh1","kind":"target","name":"IMPDH1","aka":["inosine monophosphate dehydrogenase 1","Inosine-5'-monophosphate dehydrogenase 1","sWSS2608","LCA11","RP10"],"tldr":"IMPDH1 (Inosine-5'-monophosphate dehydrogenase 1) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma, Myeloproliferative neoplasms and 2 more.","summary":"Catalyses the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumours.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.94, animal model 0.50, genetic association 0.00, clinical 0.91).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6052","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6052"},{"label":"UniProt P20839","url":"https://www.uniprot.org/uniprotkb/P20839/entry"},{"label":"NCBI Gene 3614","url":"https://www.ncbi.nlm.nih.gov/gene/3614"},{"label":"Ensembl ENSG00000106348","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106348"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia","non-hodgkin-lymphoma","myeloproliferative-neoplasms","all-leukemia","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.92. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IMPDH1","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6052","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6052","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P20839","url":"https://www.uniprot.org/uniprotkb/P20839/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000106348","url":"https://platform.opentargets.org/target/ENSG00000106348/associations","note":"association with cancer (MONDO_0004992) 0.59; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.53, acute lymphoblastic leukaemia 0.53, non-Hodgkin lymphoma 0.54, myeloproliferative neoplasm 0.53, leukaemia 0.56 (GraphQL API, CC0)"}],"hgnc":"HGNC:6052","ensembl":"ENSG00000106348","uniprot":"P20839","entrez":"3614","biology":"Catalyses the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumours. Location: Cytoplasm; Nucleus (UniProt). Locus 7q32.1 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.56 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.54 with non-Hodgkin lymphoma (MONDO_0018908)","Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076)","Acute lymphoblastic leukaemia: Open Targets association 0.53 with acute lymphoblastic leukaemia (MONDO_0004967)","Acute myeloid leukaemia: Open Targets association 0.53 with acute myeloid leukaemia (MONDO_0018874)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/impdh1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}]}}