{"entity":{"id":"import-low","kind":"trial","name":"IMPORT LOW","aka":[],"tldr":"IMPORT LOW showed that treating only the part of the breast around the tumour bed, with the same simple technique and schedule, is as safe as whole-breast radiotherapy and causes fewer changes to the breast.","summary":"IMPORT LOW randomised 2,018 women with low-risk breast cancer to whole-breast radiotherapy, whole-breast with reduced dose outside the tumour bed, or partial-breast radiotherapy only, all 40 Gy in 15 fractions with standard tangential fields. Five-year local relapse was 1.1 percent after whole-breast and 0.5 percent after partial-breast treatment, non-inferior, with fewer reported changes in breast appearance (Coles and colleagues, Lancet 2017).","status":"positive","asOf":"2026-09-16","links":[{"label":"ISRCTN12852634","url":"https://www.isrctn.com/ISRCTN12852634"},{"label":"Lancet 2017","url":"https://doi.org/10.1016/S0140-6736(17)31145-5"}],"tags":["radiation-wave2"],"related":[],"cancers":["breast-hr-positive","breast-her2-positive","tnbc"],"sections":[],"technologies":["hypofractionated-radiotherapy","imrt-igrt"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"phase":"3","setting":"Low-risk early breast cancer: partial-breast or reduced-dose radiotherapy versus whole-breast radiotherapy, 40 Gy in 15 fractions","sponsor":"Institute of Cancer Research (UK)","result":"5-year local relapse 0.5% (partial breast) vs 1.1% (whole breast), non-inferior; fewer breast changes.","yearReported":2017,"enrolled":2018,"outcomes":[{"endpoint":"Local relapse at 5 years","primary":true,"unit":"%","arms":[{"name":"Partial-breast radiotherapy","n":674,"value":0.5},{"name":"Whole-breast radiotherapy","n":674,"value":1.1}]}]},"route":"/trials/import-low/","neighbours":{"cancer":[{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"technology":[{"id":"hypofractionated-radiotherapy","kind":"technology","name":"Hypofractionated radiotherapy","route":"/technologies/hypofractionated-radiotherapy/"},{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}]}}