{"entity":{"id":"incenp","kind":"target","name":"INCENP","aka":["inner centromere protein","Inner centromere protein","FLJ31633"],"tldr":"INCENP (Inner centromere protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Acts as a scaffold regulating CPC localisation and activity.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.50, genetic association 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6058","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6058"},{"label":"UniProt Q9NQS7","url":"https://www.uniprot.org/uniprotkb/Q9NQS7/entry"},{"label":"NCBI Gene 3619","url":"https://www.ncbi.nlm.nih.gov/gene/3619"},{"label":"Ensembl ENSG00000149503","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149503"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"INCENP","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6058","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6058","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NQS7","url":"https://www.uniprot.org/uniprotkb/Q9NQS7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000149503","url":"https://platform.opentargets.org/target/ENSG00000149503/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6058","ensembl":"ENSG00000149503","uniprot":"Q9NQS7","entrez":"3619","biology":"Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Acts as a scaffold regulating CPC localisation and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB and AURKC. Location: Nucleus; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle; Midbody (UniProt). Locus 11q12.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/incenp/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}