{"entity":{"id":"indigotindisulfonate","kind":"drug","name":"Indigotindisulfonate sodium (indigo carmine)","aka":["indigotindisulfonate","indigo carmine","Bludigo"],"tldr":"A blue dye given into a vein near the end of an operation on the pelvis, so the surgeon can see blue urine coming from each ureter and check they were not damaged.","summary":"Provepharm's Bludigo (NDA 216264, first approved 8 July 2022) \"is indicated for use as a visualization aid in the cystoscopic assessment of the integrity of the ureters in adults following urological and gynecological open, robotic, or endoscopic surgical procedures\".","status":"approved","asOf":"2026-11-04","links":[{"label":"Drugs@FDA Bludigo (NDA 216264)","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216264"},{"label":"DailyMed label: Bludigo","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2b91c39d-5f15-4dcf-9d3d-b378470e6bd7"}],"tags":["contrast-agents-gaps-2026-11","diagnostic"],"related":[],"cancers":[],"sections":[],"technologies":["fluorescence-guided-surgery"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo contrast agent gap fill (Drugs@FDA, FDA labels, DailyMed, EMA register, WHO ATC index)","editedOn":"2026-11-04"},"brand":"Bludigo","modality":"Blue dye contrast agent for imaging the ureters during cystoscopy (intravenous)","mechanism":"Given into a vein, the dye is excreted by the kidneys and colours the urine blue, so urine jets from each ureteric opening can be seen in the bladder.","approvals":[{"region":"US","year":2022,"indication":"Visualisation aid in cystoscopic assessment of ureteric integrity after urological and gynaecological surgery","note":"NDA 216264; Provepharm"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/indigotindisulfonate/","neighbours":{"technology":[{"id":"fluorescence-guided-surgery","kind":"technology","name":"Fluorescence-guided surgery","route":"/technologies/fluorescence-guided-surgery/"},{"id":"ureteric-stents-and-nephrostomy","kind":"technology","name":"Ureteric stents and nephrostomy tubes for malignant ureteric obstruction (Memokath 051)","route":"/technologies/ureteric-stents-and-nephrostomy/"}]}}