{"entity":{"id":"inetetamab","kind":"drug","name":"Inetetamab","aka":["Cipterbin"],"tldr":"Inetetamab is 3SBio's HER2 antibody, approved in China in 2020 with vinorelbine for HER2-positive metastatic breast cancer.","summary":"Inetetamab (Cipterbin) is a HER2 antibody developed by 3SBio in Shenyang with an engineered Fc region for stronger antibody-dependent cellular cytotoxicity. The NMPA approved it in June 2020 in combination with vinorelbine for HER2-positive metastatic breast cancer previously treated with chemotherapy, making it the first HER2 antibody developed in China.","status":"approved","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov: trials of inetetamab","url":"https://clinicaltrials.gov/search?intr=inetetamab"}],"tags":["china","nmpa-approved"],"related":[],"cancers":["breast-her2-positive"],"sections":[],"technologies":["monoclonal-antibody"],"targets":["her2"],"drugs":[],"companies":["3sbio"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo China deep dive","editedOn":"2026-09-16"},"modality":"Anti-HER2 monoclonal antibody, Fc-engineered","mechanism":"Binds HER2 on tumour cells, blocking growth signals and recruiting immune cells; its modified Fc region strengthens antibody-dependent cell killing compared with trastuzumab.","approvals":[{"region":"CN","year":2020,"indication":"HER2-positive metastatic breast cancer after chemotherapy, with vinorelbine"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/inetetamab/","neighbours":{"cancer":[{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"}],"technology":[{"id":"monoclonal-antibody","kind":"technology","name":"Monoclonal antibodies","route":"/technologies/monoclonal-antibody/"}],"target":[{"id":"her2","kind":"target","name":"HER2","route":"/targets/her2/"}],"company":[{"id":"3sbio","kind":"company","name":"3SBio","route":"/companies/3sbio/"}]}}