{"entity":{"id":"ing1","kind":"target","name":"ING1","aka":["inhibitor of growth family member 1","Inhibitor of growth protein 1","p33ING1","p33ING1b","p24ING1c","p33","p47","p47ING1a"],"tldr":"ING1 (Inhibitor of growth protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Colorectal cancer and Endometrial cancer.","summary":"Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumour suppressor gene.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.49, somatic mutation 0.73, genetic literature 0.61). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Colorectal Adenocarcinoma, Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6062","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6062"},{"label":"UniProt Q9UK53","url":"https://www.uniprot.org/uniprotkb/Q9UK53/entry"},{"label":"NCBI Gene 3621","url":"https://www.ncbi.nlm.nih.gov/gene/3621"},{"label":"Ensembl ENSG00000153487","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153487"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["head-and-neck","colorectal","endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ING1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6062","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6062","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UK53","url":"https://www.uniprot.org/uniprotkb/Q9UK53/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000153487","url":"https://platform.opentargets.org/target/ENSG00000153487/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: head and neck squamous cell carcinoma 0.59 (GraphQL API, CC0)"},{"label":"IntOGen ING1","url":"https://www.intogen.org/search?gene=ING1","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6062","ensembl":"ENSG00000153487","uniprot":"Q9UK53","entrez":"3621","biology":"Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumour suppressor gene. Location: Nucleus (UniProt). Locus 13q34 (HGNC).","whereFound":["Head and neck squamous cell carcinoma: Open Targets association 0.59 with head and neck squamous cell carcinoma (MONDO_0010150)","Colorectal cancer: IntOGen driver in 1 cohort (COADREAD)","Endometrial cancer: IntOGen driver in 1 cohort (UCEC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/ing1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}]}}