{"entity":{"id":"inppl1","kind":"target","name":"INPPL1","aka":["inositol polyphosphate phosphatase like 1","Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2","SHIP2"],"tldr":"INPPL1 (Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Endometrial cancer.","summary":"Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyses the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Required for correct mitotic spindle orientation and therefore progression of mitosis. Plays a central role in regulation of PI3K-dependent insulin signalling, although the precise molecular mechanisms and signalling pathways remain unclear.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Endometrial Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6080","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6080"},{"label":"UniProt O15357","url":"https://www.uniprot.org/uniprotkb/O15357/entry"},{"label":"NCBI Gene 3636","url":"https://www.ncbi.nlm.nih.gov/gene/3636"},{"label":"Ensembl ENSG00000165458","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000165458"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["endometrial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"INPPL1","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6080","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6080","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15357","url":"https://www.uniprot.org/uniprotkb/O15357/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen INPPL1","url":"https://www.intogen.org/search?gene=INPPL1","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6080","ensembl":"ENSG00000165458","uniprot":"O15357","entrez":"3636","biology":"Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyses the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Required for correct mitotic spindle orientation and therefore progression of mitosis. Plays a central role in regulation of PI3K-dependent insulin signalling, although the precise molecular mechanisms and signalling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signalling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton; Membrane; Cell projection, filopodium (UniProt). Locus 11q13.4 (HGNC).","whereFound":["Endometrial cancer: IntOGen driver in 1 cohort (UCEC)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/inppl1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"endometrial","kind":"cancer","name":"Endometrial cancer","route":"/cancers/endometrial/"}]}}