{"entity":{"id":"ioncologi","kind":"company","name":"iOncologi","aka":["iOncologi, Inc.","iOncologi Inc"],"tldr":"iOncologi is a Florida company using RNA in layered fat particles to train the immune system against solid tumours. Its first programme is in an early trial in glioblastoma.","summary":"iOncologi, Inc., a clinical-stage company in Gainesville, Florida, develops RNA immunotherapies under a patent exclusively licensed from the University of Florida Research Foundation. Its multilamellar RNA nanocomplex platform delivers RNA in layered lipid particles to prime a broad immune response; IONC102 pairs the platform with off-the-shelf antigens optimised with SandboxAQ and is in phase 1 in glioblastoma, according to the company. A 2026 National Cancer Institute STTR award funds iOi7, an autologous, ex vivo-expanded immunomodulatory haematopoietic stem cell therapy, for immune checkpoint inhibitor-resistant glioblastoma, including a move to closed, scalable manufacturing.","asOf":"2026-11-04","links":[{"label":"Official website","url":"https://ioncologi.com/"},{"label":"NIH RePORTER: award 4R42CA302331-02","url":"https://reporter.nih.gov/project-details/11457448"}],"tags":[],"related":[],"cancers":["glioblastoma"],"sections":["immunotherapy"],"technologies":["shared-antigen-vaccine"],"targets":[],"drugs":["ionc102"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Company website and the NIH RePORTER record read on 4 November 2026. The glioblastoma trial the website describes was not matched to a registry record in OnCo."],"hq":"Gainesville, FL","country":"US","companyType":"biotech","website":"https://ioncologi.com/","stage":"startup","investors":[],"funding":[{"round":"Grant","year":2026,"amountUsd":1006593,"source":"https://reporter.nih.gov/project-details/11457448","note":"NCI STTR (R42) award 4R42CA302331-02: Overcoming Immune Checkpoint Blockade Resistance in Glioblastoma with a Novel Stem Cell Biotherapeutic"}]},"route":"/companies/ioncologi/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"section":[{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"technology":[{"id":"shared-antigen-vaccine","kind":"technology","name":"Off-the-shelf cancer vaccines","route":"/technologies/shared-antigen-vaccine/"}],"drug":[{"id":"ionc102","kind":"drug","name":"IONC102","route":"/drugs/ionc102/"}]}}