{"entity":{"id":"ips-hodgkin","kind":"term","name":"International Prognostic Score for advanced Hodgkin lymphoma (Hasenclever)","aka":["International Prognostic Score","IPS","Hasenclever score","Hasenclever index"],"tldr":"The International Prognostic Score counts seven factors at diagnosis of advanced Hodgkin lymphoma; the more present, the higher the risk that standard treatment will not hold the disease.","summary":"From 5,141 patients with advanced Hodgkin lymphoma treated with combination chemotherapy, Hasenclever and colleagues (New England Journal of Medicine 1998) found seven factors with similar effects: albumin below 4 g/dl, haemoglobin below 10.5 g/dl, male sex, age 45 or over, Ann Arbor stage IV, white count of 15,000/mm3 or more, and low lymphocyte count. Freedom from progression in that era fell from 84% with no factors to 42% with five or more. The authors could not identify a distinct very-high-risk group from routine features.","asOf":"2026-11-04","links":[{"label":"Hasenclever et al., A prognostic score for advanced Hodgkin's disease (N Engl J Med 1998)","url":"https://doi.org/10.1056/nejm199811193392104"}],"tags":[],"related":["lugano-classification","staging-systems"],"cancers":["hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Clinical"},"route":"/terms/ips-hodgkin/","neighbours":{"term":[{"id":"staging-systems","kind":"term","name":"Disease-specific staging and risk systems (FIGO, Ann Arbor, IPI, R-ISS, ELN, IMDC)","route":"/terms/staging-systems/"},{"id":"lugano-classification","kind":"term","name":"Lugano classification / Ann Arbor staging","route":"/terms/lugano-classification/"}],"cancer":[{"id":"hodgkin-lymphoma","kind":"cancer","name":"Hodgkin lymphoma","route":"/cancers/hodgkin-lymphoma/"}]}}