{"entity":{"id":"iqgap1","kind":"target","name":"IQGAP1","aka":["IQ motif containing GTPase activating protein 1","Ras GTPase-activating-like protein IQGAP1","p195","KIAA0051","SAR1","HUMORFA01"],"tldr":"IQGAP1 (Ras GTPase-activating-like protein IQGAP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilise microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.97, literature 0.98, genetic association 0.32, somatic mutation 0.00, animal model 0.58).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6110","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6110"},{"label":"UniProt P46940","url":"https://www.uniprot.org/uniprotkb/P46940/entry"},{"label":"NCBI Gene 8826","url":"https://www.ncbi.nlm.nih.gov/gene/8826"},{"label":"Ensembl ENSG00000140575","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140575"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IQGAP1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6110","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6110","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P46940","url":"https://www.uniprot.org/uniprotkb/P46940/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000140575","url":"https://platform.opentargets.org/target/ENSG00000140575/associations","note":"association with cancer (MONDO_0004992) 0.67;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6110","ensembl":"ENSG00000140575","uniprot":"P46940","entrez":"8826","biology":"Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilise microtubules and allow stable insertion of caveolae into the plasma membrane. Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest. Location: Cell membrane; Nucleus; Cytoplasm; Cytoplasm, cell cortex (UniProt). Locus 15q26.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/iqgap1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}