{"entity":{"id":"irf5","kind":"target","name":"IRF5","aka":["interferon regulatory factor 5","Interferon regulatory factor 5","IRF-5"],"tldr":"IRF5 (Interferon regulatory factor 5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.66).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6120","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6120"},{"label":"UniProt Q13568","url":"https://www.uniprot.org/uniprotkb/Q13568/entry"},{"label":"NCBI Gene 3663","url":"https://www.ncbi.nlm.nih.gov/gene/3663"},{"label":"Ensembl ENSG00000128604","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128604"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IRF5","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6120","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6120","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13568","url":"https://www.uniprot.org/uniprotkb/Q13568/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000128604","url":"https://platform.opentargets.org/target/ENSG00000128604/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6120","ensembl":"ENSG00000128604","uniprot":"Q13568","entrez":"3663","biology":"Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway. Key transcription factor regulating the IFN response during SARS-CoV-2 infection. Location: Cytoplasm; Nucleus (UniProt). Locus 7q32.1 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/irf5/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}