{"entity":{"id":"irx4","kind":"target","name":"IRX4","aka":["iroquois homeobox 4","Iroquois-class homeodomain protein IRX-4"],"tldr":"IRX4 (Iroquois-class homeodomain protein IRX-4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Likely to be an important mediator of ventricular differentiation during cardiac development.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.46, genetic association 0.84).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6129","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6129"},{"label":"UniProt P78413","url":"https://www.uniprot.org/uniprotkb/P78413/entry"},{"label":"NCBI Gene 50805","url":"https://www.ncbi.nlm.nih.gov/gene/50805"},{"label":"Ensembl ENSG00000113430","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113430"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IRX4","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6129","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6129","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P78413","url":"https://www.uniprot.org/uniprotkb/P78413/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000113430","url":"https://platform.opentargets.org/target/ENSG00000113430/associations","note":"association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: prostate cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:6129","ensembl":"ENSG00000113430","uniprot":"P78413","entrez":"50805","biology":"Likely to be an important mediator of ventricular differentiation during cardiac development. Location: Nucleus (UniProt). Locus 5p15.33 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/irx4/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}