{"entity":{"id":"isosulfan-blue","kind":"drug","name":"Isosulfan blue (lymphatic mapping dye)","aka":["isosulfan blue","Lymphazurin","isosulphan blue"],"tldr":"A blue dye injected near a tumour before surgery. It travels to the nearest lymph nodes and stains them blue, helping the surgeon find the sentinel node.","summary":"Lymphazurin (NDA 018310, Covidien, first approved 29 July 1981) and generic isosulfan blue injection 1% (for example ANDA 090874) are labelled as \"an adjunct to lymphography in: primary and secondary lymphedema of the extremities; chyluria, chylous ascites or chylothorax; lymph node involvement by primary or secondary neoplasm; lymph node response to therapeutic modalities\".","status":"approved","asOf":"2026-11-04","links":[{"label":"Drugs@FDA Lymphazurin (NDA 018310)","url":"https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=018310"},{"label":"DailyMed label: Isosulfan blue injection 1%","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0391e544-3633-48df-9f3a-ed16183125b1"}],"tags":["contrast-agents-gaps-2026-11","diagnostic"],"related":[],"cancers":[],"sections":[],"technologies":["sentinel-node","magnetic-sentinel-node-tracer"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["sentinel-lymph-node-biopsy"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo contrast agent gap fill (Drugs@FDA, FDA labels, DailyMed, EMA register, WHO ATC index)","editedOn":"2026-11-04"},"brand":"Lymphazurin","modality":"Blue dye for lymphatic mapping (subcutaneous injection)","mechanism":"Injected under the skin, the dye binds to proteins and is carried in lymphatic vessels, staining them and the nodes they drain to blue.","approvals":[{"region":"US","year":1981,"indication":"Adjunct to lymphography, including lymph node involvement by primary or secondary neoplasm","note":"NDA 018310; Covidien"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/isosulfan-blue/","neighbours":{"technology":[{"id":"magnetic-sentinel-node-tracer","kind":"technology","name":"Magnetic tracer for sentinel lymph node biopsy (Magtrace and Sentimag)","route":"/technologies/magnetic-sentinel-node-tracer/"},{"id":"sentinel-node","kind":"technology","name":"Sentinel lymph node biopsy","route":"/technologies/sentinel-node/"}],"term":[{"id":"sentinel-lymph-node-biopsy","kind":"term","name":"Sentinel node biopsy","route":"/terms/sentinel-lymph-node-biopsy/"}]}}