{"entity":{"id":"itga2b","kind":"target","name":"ITGA2B","aka":["integrin subunit alpha 2b","Integrin alpha-IIb","CD41B","CD41","PPP1R93","GPIIb","GP2B"],"tldr":"ITGA2B (Integrin alpha-IIb) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognises the sequence R-G-D in a wide array of ligands. It recognises the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.81, affected pathway 0.97, animal model 0.55, genetic association 0.07).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6138","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6138"},{"label":"UniProt P08514","url":"https://www.uniprot.org/uniprotkb/P08514/entry"},{"label":"NCBI Gene 3674","url":"https://www.ncbi.nlm.nih.gov/gene/3674"},{"label":"Ensembl ENSG00000005961","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000005961"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ITGA2B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6138","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6138","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P08514","url":"https://www.uniprot.org/uniprotkb/P08514/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000005961","url":"https://platform.opentargets.org/target/ENSG00000005961/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6138","ensembl":"ENSG00000005961","uniprot":"P08514","entrez":"3674","biology":"Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognises the sequence R-G-D in a wide array of ligands. It recognises the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Integrin ITGA2B:ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets. Location: Cell membrane (UniProt). Locus 17q21.31 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/itga2b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}