{"entity":{"id":"itga6","kind":"target","name":"ITGA6","aka":["integrin subunit alpha 6","Integrin alpha-6","CD49f","VLA-6","ITGA6A","ITGA6B"],"tldr":"ITGA6 (Integrin alpha-6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.","summary":"Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6142","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6142"},{"label":"UniProt P23229","url":"https://www.uniprot.org/uniprotkb/P23229/entry"},{"label":"NCBI Gene 3655","url":"https://www.ncbi.nlm.nih.gov/gene/3655"},{"label":"Ensembl ENSG00000091409","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091409"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ITGA6","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6142","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6142","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P23229","url":"https://www.uniprot.org/uniprotkb/P23229/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000091409","url":"https://platform.opentargets.org/target/ENSG00000091409/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: prostate cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:6142","ensembl":"ENSG00000091409","uniprot":"P23229","entrez":"3655","biology":"Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signalling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signalling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signalling. Location: Cell membrane (UniProt). Locus 2q31.1 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)"],"targetClass":"other","prevalence":[]},"route":"/targets/itga6/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}