{"entity":{"id":"itgav","kind":"target","name":"ITGAV","aka":["integrin subunit alpha V","Integrin alpha-V","CD51","MSK8"],"tldr":"ITGAV (Integrin alpha-V) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer.","summary":"The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognise the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signalling.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Stomach Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6150","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6150"},{"label":"UniProt P06756","url":"https://www.uniprot.org/uniprotkb/P06756/entry"},{"label":"NCBI Gene 3685","url":"https://www.ncbi.nlm.nih.gov/gene/3685"},{"label":"Ensembl ENSG00000138448","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138448"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ITGAV","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:6150","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6150","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P06756","url":"https://www.uniprot.org/uniprotkb/P06756/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ITGAV","url":"https://www.intogen.org/search?gene=ITGAV","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6150","ensembl":"ENSG00000138448","uniprot":"P06756","entrez":"3685","biology":"The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognise the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signalling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signalling. ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signalling. ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signalling. Location: Cell membrane; Cell junction, focal adhesion (UniProt). Locus 2q32.1 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/itgav/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}