{"entity":{"id":"jag1","kind":"target","name":"JAG1","aka":["jagged canonical Notch ligand 1","HJ1","CD339","JAGL1"],"tldr":"JAG1 (jagged canonical Notch ligand 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Ligand for multiple Notch receptors and involved in the mediation of Notch signalling. May be involved in cell-fate decisions during haematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development.\n\nOpen Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.78, animal model 0.59, genetic association 0.54).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6188","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6188"},{"label":"UniProt P78504","url":"https://www.uniprot.org/uniprotkb/P78504/entry"},{"label":"NCBI Gene 182","url":"https://www.ncbi.nlm.nih.gov/gene/182"},{"label":"Ensembl ENSG00000101384","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101384"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"JAG1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6188","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6188","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P78504","url":"https://www.uniprot.org/uniprotkb/P78504/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000101384","url":"https://platform.opentargets.org/target/ENSG00000101384/associations","note":"association with cancer (MONDO_0004992) 0.68;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6188","ensembl":"ENSG00000101384","uniprot":"P78504","entrez":"182","biology":"Ligand for multiple Notch receptors and involved in the mediation of Notch signalling. May be involved in cell-fate decisions during haematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Location: Membrane; Cell membrane (UniProt). Locus 20p12.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/jag1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}