{"entity":{"id":"jazf1","kind":"target","name":"JAZF1","aka":["JAZF zinc finger 1","Juxtaposed with another zinc finger protein 1","TIP27","DKFZp761K2222","ZNF802"],"tldr":"JAZF1 (Juxtaposed with another zinc finger protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Prostate cancer.","summary":"Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.68, somatic mutation 0.49).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:28917","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28917"},{"label":"UniProt Q86VZ6","url":"https://www.uniprot.org/uniprotkb/Q86VZ6/entry"},{"label":"NCBI Gene 221895","url":"https://www.ncbi.nlm.nih.gov/gene/221895"},{"label":"Ensembl ENSG00000153814","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153814"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"JAZF1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:28917","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28917","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q86VZ6","url":"https://www.uniprot.org/uniprotkb/Q86VZ6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000153814","url":"https://platform.opentargets.org/target/ENSG00000153814/associations","note":"association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: prostate cancer 0.52, skin cancer 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:28917","ensembl":"ENSG00000153814","uniprot":"Q86VZ6","entrez":"221895","biology":"Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity. Location: Nucleus (UniProt). Locus 7p15.2-p15.1 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/jazf1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}