{"entity":{"id":"jean-pascal-machiels","kind":"person","name":"Jean-Pascal Machiels","aka":[],"tldr":"Brussels oncologist who led KEYNOTE-412, the trial that tested adding pembrolizumab to chemoradiotherapy for locally advanced head and neck cancer.","summary":"Jean-Pascal Machiels heads medical oncology at Cliniques universitaires Saint-Luc in Brussels and chairs the EORTC head and neck cancer group. He was first author of the 2024 Lancet Oncology report of KEYNOTE-412, the phase 3 trial of pembrolizumab with and after cisplatin-based chemoradiotherapy in locally advanced head and neck squamous-cell carcinoma, which did not reach statistical significance for event-free survival, and of the European guidelines for the disease.","asOf":"2026-09-18","links":[],"tags":["head-and-neck","immunotherapy","trialist"],"related":[],"cancers":["hpv-negative-head-and-neck-cancer","head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["king-albert-ii-cancer-institute"],"pathways":[],"terms":[],"trials":["keynote-412"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Head of Medical Oncology, Cliniques universitaires Saint-Luc, Brussels","institutionId":"king-albert-ii-cancer-institute","specialisms":["Head and neck cancer","Chemoradiotherapy with immunotherapy","Early-phase trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Machiels%5BAuthor%5D"}],"papers":[]},"route":"/people/jean-pascal-machiels/","neighbours":{"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"hpv-negative-head-and-neck-cancer","kind":"cancer","name":"HPV-negative head and neck squamous cell carcinoma (including HPV-negative oropharyngeal cancer)","route":"/cancers/hpv-negative-head-and-neck-cancer/"}],"institution":[{"id":"king-albert-ii-cancer-institute","kind":"institution","name":"King Albert II Cancer Institute, Cliniques universitaires Saint-Luc","route":"/institutions/king-albert-ii-cancer-institute/"}],"trial":[{"id":"keynote-412","kind":"trial","name":"KEYNOTE-412","route":"/trials/keynote-412/"}]}}