{"entity":{"id":"jun","kind":"target","name":"JUN","aka":["Jun proto-oncogene, AP-1 transcription factor subunit","Transcription factor Jun","c-Jun","AP-1"],"tldr":"JUN (Transcription factor Jun) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Skin cancer and Melanoma.","summary":"Transcription factor that recognises and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3'. Heterodimerises with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity. Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signalling pathway.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Irbesartan. Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.71, animal model 0.33, somatic mutation 0.96).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6204","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6204"},{"label":"UniProt P05412","url":"https://www.uniprot.org/uniprotkb/P05412/entry"},{"label":"NCBI Gene 3725","url":"https://www.ncbi.nlm.nih.gov/gene/3725"},{"label":"Ensembl ENSG00000177606","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177606"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["colorectal","skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"JUN","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6204","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6204","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P05412","url":"https://www.uniprot.org/uniprotkb/P05412/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene JUN","url":"https://civicdb.org/features/3094","note":"1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Adenocarcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000177606","url":"https://platform.opentargets.org/target/ENSG00000177606/associations","note":"association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: colorectal cancer 0.54, melanoma 0.56, skin cancer 0.56 (GraphQL API, CC0)"}],"hgnc":"HGNC:6204","ensembl":"ENSG00000177606","uniprot":"P05412","entrez":"3725","biology":"Transcription factor that recognises and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3'. Heterodimerises with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity. Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signalling pathway. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signalling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells. Location: Nucleus (UniProt). Locus 1p32.1 (HGNC).","whereFound":["Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575); CIViC evidence names this disease","Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.56 with melanoma (MONDO_0005105)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/jun/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}