{"entity":{"id":"jy231","kind":"drug","name":"JY231","aka":["JY231 Injection"],"tldr":"JY231 is an experimental in vivo CAR-T therapy from Genocury Biotech, in early studies for B-cell non-Hodgkin lymphoma and B-cell acute lymphoblastic leukaemia.","summary":"JY231 is an in vivo CAR-T (an infusion that makes CAR-T cells inside the body) from Genocury Biotech. The registry says the infusion produces CAR-T cells inside the body; it does not state which protein the CAR recognises. Two investigator-initiated early exploratory studies (NCT06678282, NCT06890065; the registry gives the phase as not applicable) are recruiting. Whether it works in people has not been established.","status":"phase-1","asOf":"2026-11-04","links":[{"label":"ClinicalTrials.gov NCT06678282","url":"https://clinicaltrials.gov/study/NCT06678282"},{"label":"ClinicalTrials.gov NCT06890065","url":"https://clinicaltrials.gov/study/NCT06890065"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["non-hodgkin-lymphoma","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":["genocury-biotech"],"institutions":[],"pathways":[],"terms":[],"trials":["nct06678282","nct06890065"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo startup monitors, investor portfolios (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-04"},"code":"JY231","modality":"In vivo CAR-T (an infusion that makes CAR-T cells inside the body)","mechanism":"The registry says the infusion produces CAR-T cells inside the body; it does not state which protein the CAR recognises.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/jy231/","neighbours":{"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"}],"company":[{"id":"genocury-biotech","kind":"company","name":"Genocury Biotech","route":"/companies/genocury-biotech/"}],"trial":[{"id":"nct06678282","kind":"trial","name":"JY231(JY231) Injection for the Treatment of Relapsed or Refractory B Cell Lymphoma/ Leukemia","route":"/trials/nct06678282/"},{"id":"nct06890065","kind":"trial","name":"JY231(JY231) Injection for the Treatment of Relapsed/Refractory B Cell Lymphoma/ Leukemia","route":"/trials/nct06890065/"}]}}