{"entity":{"id":"kat2a","kind":"target","name":"KAT2A","aka":["lysine acetyltransferase 2A","Histone acetyltransferase KAT2A","GCN5","PCAF-b","GCN5L2"],"tldr":"KAT2A (Histone acetyltransferase KAT2A) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Protein lysine acyltransferase that catalyses acetylation of histone and non-histone proteins using acetyl-CoA. Also catalyses acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA. Acts as a histone lysine succinyltransferase: catalyses succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.95, affected pathway 0.80, animal model 0.30, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4201","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4201"},{"label":"UniProt Q92830","url":"https://www.uniprot.org/uniprotkb/Q92830/entry"},{"label":"NCBI Gene 2648","url":"https://www.ncbi.nlm.nih.gov/gene/2648"},{"label":"Ensembl ENSG00000108773","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108773"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KAT2A","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:4201","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4201","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92830","url":"https://www.uniprot.org/uniprotkb/Q92830/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000108773","url":"https://platform.opentargets.org/target/ENSG00000108773/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"hgnc":"HGNC:4201","ensembl":"ENSG00000108773","uniprot":"Q92830","entrez":"2648","biology":"Protein lysine acyltransferase that catalyses acetylation of histone and non-histone proteins using acetyl-CoA. Also catalyses acyl-CoA-dependent acylation of lysine residues in proteins using alternative acyl-CoA donors, including propionyl-CoA, butyryl-CoA, succinyl-CoA, glutaryl-CoA, crotonyl-CoA and lactoyl-CoA. Acts as a histone lysine succinyltransferase: catalyses succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes. Succinylation of histones gives a specific tag for epigenetic transcription activation. Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation. In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase. Location: Nucleus; Chromosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 17q21.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/kat2a/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}