{"entity":{"id":"kat2b","kind":"target","name":"KAT2B","aka":["lysine acetyltransferase 2B","Histone acetyltransferase KAT2B","P/CAF","GCN5","GCN5L"],"tldr":"KAT2B (Histone acetyltransferase KAT2B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac).\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.94, genetic association 0.30).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:8638","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8638"},{"label":"UniProt Q92831","url":"https://www.uniprot.org/uniprotkb/Q92831/entry"},{"label":"NCBI Gene 8850","url":"https://www.ncbi.nlm.nih.gov/gene/8850"},{"label":"Ensembl ENSG00000114166","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114166"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KAT2B","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:8638","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8638","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92831","url":"https://www.uniprot.org/uniprotkb/Q92831/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000114166","url":"https://platform.opentargets.org/target/ENSG00000114166/associations","note":"association with cancer (MONDO_0004992) 0.64;  (GraphQL API, CC0)"}],"hgnc":"HGNC:8638","ensembl":"ENSG00000114166","uniprot":"Q92831","entrez":"8850","biology":"Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Has a a strong preference for acetylation of H3 at 'Lys-9' (H3K9ac). Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-BMAL1 and CLOCK-BMAL1 heterodimers. Location: Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm (UniProt). Locus 3p24.3 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/kat2b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}