{"entity":{"id":"kat6a","kind":"target","name":"KAT6A","aka":["lysine acetyltransferase 6A","Histone acetyltransferase KAT6A","ZNF220","RUNXBP2","MYST3"],"tldr":"KAT6A (Histone acetyltransferase KAT6A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Skin cancer, Breast cancer and 5 more.","summary":"Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.98, animal model 0.48, genetic association 0.00, somatic mutation 0.86). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Oesophageal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13013","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13013"},{"label":"UniProt Q92794","url":"https://www.uniprot.org/uniprotkb/Q92794/entry"},{"label":"NCBI Gene 7994","url":"https://www.ncbi.nlm.nih.gov/gene/7994"},{"label":"Ensembl ENSG00000083168","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000083168"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["esophageal","skin-cancer","breast-cancer","colorectal","lung-cancer","ovarian","oesophageal-adenocarcinoma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KAT6A","role":["tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:13013","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13013","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92794","url":"https://www.uniprot.org/uniprotkb/Q92794/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000083168","url":"https://platform.opentargets.org/target/ENSG00000083168/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.53, ovarian cancer 0.52, melanoma 0.56, skin cancer 0.57, breast cancer 0.55, lung cancer 0.53 (GraphQL API, CC0)"},{"label":"IntOGen KAT6A","url":"https://www.intogen.org/search?gene=KAT6A","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:13013","ensembl":"ENSG00000083168","uniprot":"Q92794","entrez":"7994","biology":"Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. May play a role in leukemogenic gene transcription. Location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus, PML body (UniProt). Locus 8p11.21 (HGNC).","whereFound":["Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)","Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)","Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)","Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903)","Ovarian cancer: Open Targets association 0.52 with ovarian cancer (MONDO_0008170)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/kat6a/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}