{"entity":{"id":"kat6b","kind":"target","name":"KAT6B","aka":["lysine acetyltransferase 6B","Histone acetyltransferase KAT6B","querkopf","qkf","Morf","MOZ2","MYST4"],"tldr":"KAT6B (Histone acetyltransferase KAT6B) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Nasopharyngeal carcinoma, Prostate cancer and 4 more.","summary":"Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development.\n\nOpen Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.89, animal model 0.28, genetic association 0.00, somatic mutation 0.87). IntOGen calls it a driver in 5 cohorts (1 activating, 4 loss-of-function), covering Invasive Breast Carcinoma, Low-Grade Glioma, NOS, Medulloblastoma, Nasopharyngeal Carcinoma, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17582","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17582"},{"label":"UniProt Q8WYB5","url":"https://www.uniprot.org/uniprotkb/Q8WYB5/entry"},{"label":"NCBI Gene 23522","url":"https://www.ncbi.nlm.nih.gov/gene/23522"},{"label":"Ensembl ENSG00000156650","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156650"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["breast-cancer","nasopharyngeal","prostate","skin-cancer","colorectal","medulloblastoma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KAT6B","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:17582","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17582","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WYB5","url":"https://www.uniprot.org/uniprotkb/Q8WYB5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000156650","url":"https://platform.opentargets.org/target/ENSG00000156650/associations","note":"association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: colorectal cancer 0.51, melanoma 0.51, skin cancer 0.55, breast cancer 0.58 (GraphQL API, CC0)"},{"label":"IntOGen KAT6B","url":"https://www.intogen.org/search?gene=KAT6B","note":"driver in 5 cohorts (Act 1, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:17582","ensembl":"ENSG00000156650","uniprot":"Q8WYB5","entrez":"23522","biology":"Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Location: Nucleus (UniProt). Locus 10q22.2 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)","Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)","Medulloblastoma: IntOGen driver in 1 cohort (MBL)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/kat6b/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}