{"entity":{"id":"kcna3","kind":"target","name":"KCNA3","aka":["potassium voltage-gated channel subfamily A member 3","Potassium voltage-gated channel subfamily A member 3","Kv1.3","MK3","HLK3","HPCN3","RP11-284N8.3"],"tldr":"KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Mediates the voltage-dependent potassium ion permeability of excitable membranes.\n\nOpen Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.47, clinical 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6221","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6221"},{"label":"UniProt P22001","url":"https://www.uniprot.org/uniprotkb/P22001/entry"},{"label":"NCBI Gene 3738","url":"https://www.ncbi.nlm.nih.gov/gene/3738"},{"label":"Ensembl ENSG00000177272","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177272"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KCNA3","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6221","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6221","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P22001","url":"https://www.uniprot.org/uniprotkb/P22001/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000177272","url":"https://platform.opentargets.org/target/ENSG00000177272/associations","note":"association with cancer (MONDO_0004992) 0.55;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6221","ensembl":"ENSG00000177272","uniprot":"P22001","entrez":"3738","biology":"Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Lacks voltage-gated potassium channel activity. Location: Cell membrane; Cytoplasm, perinuclear region (UniProt). Locus 1p13.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/kcna3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}