{"entity":{"id":"kcnc2","kind":"target","name":"KCNC2","aka":["potassium voltage-gated channel subfamily C member 2","Voltage-gated potassium channel KCNC2","Kv3.2"],"tldr":"KCNC2 (Voltage-gated potassium channel KCNC2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarisation and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly.\n\nOpen Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.14, genetic association 0.22, clinical 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6234","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6234"},{"label":"UniProt Q96PR1","url":"https://www.uniprot.org/uniprotkb/Q96PR1/entry"},{"label":"NCBI Gene 3747","url":"https://www.ncbi.nlm.nih.gov/gene/3747"},{"label":"Ensembl ENSG00000166006","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166006"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KCNC2","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6234","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6234","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96PR1","url":"https://www.uniprot.org/uniprotkb/Q96PR1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000166006","url":"https://platform.opentargets.org/target/ENSG00000166006/associations","note":"association with cancer (MONDO_0004992) 0.51;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6234","ensembl":"ENSG00000166006","uniprot":"Q96PR1","entrez":"3747","biology":"Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarisation and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Location: Cell membrane; Membrane; Perikaryon; Cell projection, axon (UniProt). Locus 12q21.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/kcnc2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}