{"entity":{"id":"kcnh1","kind":"target","name":"KCNH1","aka":["potassium voltage-gated channel subfamily H member 1","Voltage-gated delayed rectifier potassium channel KCNH1","Kv10.1","eag","h-eag","eag1","hEAG","K(V)10.1"],"tldr":"KCNH1 (Voltage-gated delayed rectifier potassium channel KCNH1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarisation, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.33, clinical 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6250","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6250"},{"label":"UniProt O95259","url":"https://www.uniprot.org/uniprotkb/O95259/entry"},{"label":"NCBI Gene 3756","url":"https://www.ncbi.nlm.nih.gov/gene/3756"},{"label":"Ensembl ENSG00000143473","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143473"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KCNH1","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6250","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6250","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O95259","url":"https://www.uniprot.org/uniprotkb/O95259/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000143473","url":"https://platform.opentargets.org/target/ENSG00000143473/associations","note":"association with cancer (MONDO_0004992) 0.54;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6250","ensembl":"ENSG00000143473","uniprot":"O95259","entrez":"3756","biology":"Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarisation, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve. Channel properties are modulated by subunit assembly. Location: Cell membrane; Nucleus inner membrane; Cell projection, dendrite; Cell projection, axon (UniProt). Locus 1q32.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/kcnh1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}