{"entity":{"id":"kcnh7","kind":"target","name":"KCNH7","aka":["potassium voltage-gated channel subfamily H member 7","Voltage-gated inwardly rectifying potassium channel KCNH7","Kv11.3","HERG3","erg3"],"tldr":"KCNH7 (Voltage-gated inwardly rectifying potassium channel KCNH7) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.11, genetic association 0.27, clinical 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18863","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18863"},{"label":"UniProt Q9NS40","url":"https://www.uniprot.org/uniprotkb/Q9NS40/entry"},{"label":"NCBI Gene 90134","url":"https://www.ncbi.nlm.nih.gov/gene/90134"},{"label":"Ensembl ENSG00000184611","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184611"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KCNH7","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:18863","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18863","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NS40","url":"https://www.uniprot.org/uniprotkb/Q9NS40/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000184611","url":"https://platform.opentargets.org/target/ENSG00000184611/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"hgnc":"HGNC:18863","ensembl":"ENSG00000184611","uniprot":"Q9NS40","entrez":"90134","biology":"Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification. Location: Cell membrane (UniProt). Locus 2q24.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/kcnh7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}