{"entity":{"id":"kcnh8","kind":"target","name":"KCNH8","aka":["potassium voltage-gated channel subfamily H member 8","Voltage-gated delayed rectifier potassium channel KCNH8","Kv12.1","elk3"],"tldr":"KCNH8 (Voltage-gated delayed rectifier potassium channel KCNH8) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.12, animal model 0.45, genetic association 0.49, clinical 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18864","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18864"},{"label":"UniProt Q96L42","url":"https://www.uniprot.org/uniprotkb/Q96L42/entry"},{"label":"NCBI Gene 131096","url":"https://www.ncbi.nlm.nih.gov/gene/131096"},{"label":"Ensembl ENSG00000183960","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183960"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KCNH8","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:18864","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18864","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96L42","url":"https://www.uniprot.org/uniprotkb/Q96L42/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000183960","url":"https://platform.opentargets.org/target/ENSG00000183960/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:18864","ensembl":"ENSG00000183960","uniprot":"Q96L42","entrez":"131096","biology":"Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials. Activation is strongly dependent on the pH of the external solution. Location: Membrane (UniProt). Locus 3p24.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/kcnh8/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}