{"entity":{"id":"kcnq3","kind":"target","name":"KCNQ3","aka":["potassium voltage-gated channel subfamily Q member 3","Potassium voltage-gated channel subfamily KQT member 3","Kv7.3","EBN2"],"tldr":"KCNQ3 (Potassium voltage-gated channel subfamily KQT member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers. The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.61, genetic association 0.41, somatic mutation 0.23, clinical 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6297","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6297"},{"label":"UniProt O43525","url":"https://www.uniprot.org/uniprotkb/O43525/entry"},{"label":"NCBI Gene 3786","url":"https://www.ncbi.nlm.nih.gov/gene/3786"},{"label":"Ensembl ENSG00000184156","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184156"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KCNQ3","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6297","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6297","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O43525","url":"https://www.uniprot.org/uniprotkb/O43525/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000184156","url":"https://platform.opentargets.org/target/ENSG00000184156/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6297","ensembl":"ENSG00000184156","uniprot":"O43525","entrez":"3786","biology":"Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers. The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+). Suppressed by activation of M1 muscarinic acetylcholine receptors. Location: Cell membrane (UniProt). Locus 8q24.22 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/kcnq3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}