{"entity":{"id":"kdm5a","kind":"target","name":"KDM5A","aka":["lysine demethylase 5A","Lysine-specific demethylase 5A","RBBP2","JARID1A"],"tldr":"KDM5A (Lysine-specific demethylase 5A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Leukaemia, Lung cancer and 3 more.","summary":"Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.98). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Gallbladder Cancer.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:9886","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9886"},{"label":"UniProt P29375","url":"https://www.uniprot.org/uniprotkb/P29375/entry"},{"label":"NCBI Gene 5927","url":"https://www.ncbi.nlm.nih.gov/gene/5927"},{"label":"Ensembl ENSG00000073614","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000073614"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["skin-cancer","leukaemia","lung-cancer","colorectal","gallbladder","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["drug-tolerant-persisters"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KDM5A","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:9886","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9886","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P29375","url":"https://www.uniprot.org/uniprotkb/P29375/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000073614","url":"https://platform.opentargets.org/target/ENSG00000073614/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: colorectal cancer 0.51, melanoma 0.52, skin cancer 0.55, lung cancer 0.54, leukaemia 0.54 (GraphQL API, CC0)"},{"label":"IntOGen KDM5A","url":"https://www.intogen.org/search?gene=KDM5A","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:9886","ensembl":"ENSG00000073614","uniprot":"P29375","entrez":"5927","biology":"Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation. Location: Nucleus, nucleolus; Nucleus (UniProt). Locus 12p13.33 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)","Lung cancer: Open Targets association 0.54 with lung cancer (MONDO_0008903)","Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)","Gallbladder cancer: IntOGen driver in 1 cohort (GBC)","Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/kdm5a/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gallbladder","kind":"cancer","name":"Gallbladder cancer","route":"/cancers/gallbladder/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"pathway":[{"id":"drug-tolerant-persisters","kind":"pathway","name":"Drug-tolerant persister cells","route":"/pathways/drug-tolerant-persisters/"}]}}