{"entity":{"id":"kdm5c","kind":"target","name":"KDM5C","aka":["lysine demethylase 5C","Lysine-specific demethylase 5C","DXS1272E","XE169","JARID1C","MRX13"],"tldr":"KDM5C (Lysine-specific demethylase 5C) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma, Head and neck squamous cell carcinoma, Ovarian cancer and 5 more.","summary":"Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Everolimus, Capivasertib and Sunitinib. Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.98, animal model 0.44, genetic association 0.00, somatic mutation 0.96). IntOGen calls it a driver in 10 cohorts (1 activating, 9 loss-of-function), covering Renal Clear Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Lung Adenocarcinoma, Ovarian Epithelial Tumour, Pancreatic Adenocarcinoma, Plasma Cell Myeloma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11114","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11114"},{"label":"UniProt P41229","url":"https://www.uniprot.org/uniprotkb/P41229/entry"},{"label":"NCBI Gene 8242","url":"https://www.ncbi.nlm.nih.gov/gene/8242"},{"label":"Ensembl ENSG00000126012","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126012"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["rcc","head-and-neck","ovarian","pancreatic","multiple-myeloma","skin-cancer","colorectal","clear-cell-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 9 cohorts; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KDM5C","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11114","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11114","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P41229","url":"https://www.uniprot.org/uniprotkb/P41229/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KDM5C","url":"https://civicdb.org/features/6538","note":"2 evidence items, 0 assertions, 2 variants; diseases: Oestrogen Receptor-positive Breast Cancer, Renal Cell Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000126012","url":"https://platform.opentargets.org/target/ENSG00000126012/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.53, renal cell carcinoma 0.68, skin cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen KDM5C","url":"https://www.intogen.org/search?gene=KDM5C","note":"driver in 10 cohorts (Act 1, LoF 9); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:11114","ensembl":"ENSG00000126012","uniprot":"P41229","entrez":"8242","biology":"Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Location: Nucleus (UniProt). Locus Xp11.22 (HGNC).","whereFound":["Renal cell carcinoma: Open Targets association 0.68 with renal cell carcinoma (MONDO_0005086); CIViC evidence names this disease","Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Ovarian cancer: IntOGen driver in 1 cohort (OVT)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/kdm5c/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}