{"entity":{"id":"ketamine","kind":"drug","name":"Ketamine","aka":[],"tldr":"Ketamine is an anaesthetic used for sedation and pain relief during procedures, including in children having cancer care procedures, given by staff trained in anaesthesia.","summary":"The Ketalar label covers use as the sole anaesthetic for diagnostic and surgical procedures that do not need muscle relaxation, induction of anaesthesia, and as a supplement to other anaesthetics. NICE CG112 requires a professional trained in delivering anaesthetic agents to be available when opioids are combined with ketamine for sedation in under-19s, and advises against routinely using ketamine or opioids for painless imaging. The Ketalar NDA was approved on 19 February 1970.","status":"approved","asOf":"2026-11-11","wikipedia":"https://en.wikipedia.org/wiki/Ketamine","links":[{"label":"US label (DailyMed): Ketalar","url":"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=14e8f864-8b8a-4e7e-8439-e510d3107063"},{"label":"NICE CG112: Sedation in under 19s, using sedation for diagnostic and therapeutic procedures, recommendations","url":"https://www.nice.org.uk/guidance/cg112/chapter/Recommendations"}],"tags":["supportive","generic","supportive-care-gaps-2026-11"],"related":["propofol","midazolam"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo supportive care gap fill (DailyMed, openFDA, Drugs@FDA, emc SmPCs, NICE, ESMO, ASCO, MASCC, SITC, ASTCT, ITAC, Europe PMC)","editedOn":"2026-11-11"},"brand":"Ketalar","modality":"Intravenous or intramuscular general anaesthetic","supportive":true,"mechanism":"A dissociative anaesthetic that blocks NMDA receptors.","approvals":[{"region":"US","year":1970,"indication":"Sole anaesthetic for procedures not requiring muscle relaxation; induction of anaesthesia; supplement to other anaesthetics","note":"Year is the Ketalar NDA 016812 approval (Drugs@FDA)"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ketamine/","neighbours":{"drug":[{"id":"midazolam","kind":"drug","name":"Midazolam","route":"/drugs/midazolam/"},{"id":"propofol","kind":"drug","name":"Propofol","route":"/drugs/propofol/"}]}}