{"entity":{"id":"kh815","kind":"drug","name":"KH815","aka":[],"tldr":"An experimental antibody drug that carries two cancer-killing payloads to cells carrying TROP2. A first human study is registered but is still listed as not yet recruiting in an older record.","summary":"KH815 is a TROP2-directed dual-payload ADC from Chengdu Kanghong Biotech. AACR 2025 abstract 1586 describes TOP1 and RNA polymerase II inhibitor payloads and preclinical tumor-model and non-GLP primate findings; those findings do not establish human safety or comparative benefit. Its registered phase 1 study NCT06885645 plans 30 participants with advanced solid tumors. The record last posted 3 April 2025 still says NOT_YET_RECRUITING when checked 6 October 2026, with an estimated start of 30 April 2025 and no posted results. Registration and a past estimated start do not establish that dosing has begun; current recruitment requires sponsor confirmation.","status":"phase-1","asOf":"2026-10-06","links":[{"label":"AACR 2025 abstract 1586: KH815 payloads and preclinical evidence","url":"https://doi.org/10.1158/1538-7445.am2025-1586"},{"label":"ClinicalTrials.gov NCT06885645","url":"https://clinicaltrials.gov/study/NCT06885645"}],"tags":["pipeline","dual-payload"],"related":[],"cancers":[],"sections":[],"technologies":["adc","dual-payload-adc"],"targets":["trop2"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct06885645"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"code":"KH815","modality":"ADC","payload":"Topoisomerase I inhibitor and RNA polymerase II inhibitor","mechanism":"A humanized TROP2-directed hRS7 antibody delivers a topoisomerase I inhibitor and an RNA polymerase II inhibitor. The two payload classes act on DNA damage and RNA synthesis, respectively.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/kh815/","neighbours":{"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"},{"id":"dual-payload-adc","kind":"technology","name":"Dual-payload ADC","route":"/technologies/dual-payload-adc/"}],"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"trial":[{"id":"nct06885645","kind":"trial","name":"KH815 first-in-human study","route":"/trials/nct06885645/"}]}}