{"entity":{"id":"kiaa1549","kind":"target","name":"KIAA1549","aka":["UPF0606 protein KIAA1549"],"tldr":"KIAA1549 (UPF0606 protein KIAA1549) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"May play a role in photoreceptor function.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.25, affected pathway 0.89, genetic association 0.00, somatic mutation 0.50).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:22219","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22219"},{"label":"UniProt Q9HCM3","url":"https://www.uniprot.org/uniprotkb/Q9HCM3/entry"},{"label":"NCBI Gene 57670","url":"https://www.ncbi.nlm.nih.gov/gene/57670"},{"label":"Ensembl ENSG00000122778","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000122778"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["firefly-1"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KIAA1549","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:22219","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22219","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HCM3","url":"https://www.uniprot.org/uniprotkb/Q9HCM3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000122778","url":"https://platform.opentargets.org/target/ENSG00000122778/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:22219","ensembl":"ENSG00000122778","uniprot":"Q9HCM3","entrez":"57670","biology":"May play a role in photoreceptor function. Location: Membrane; Cell projection, cilium (UniProt). Locus 7q34 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/kiaa1549/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"trial":[{"id":"firefly-1","kind":"trial","name":"FIREFLY-1","route":"/trials/firefly-1/"}]}}