{"entity":{"id":"kitlg","kind":"target","name":"KITLG","aka":["KIT ligand","Kit ligand","Kitl","KL-1","FPH2","DFNA69"],"tldr":"KITLG (Kit ligand) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Testicular germ cell tumours.","summary":"Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, haematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signalling pathways.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.61, animal model 0.55, genetic association 0.68).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6343","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6343"},{"label":"UniProt P21583","url":"https://www.uniprot.org/uniprotkb/P21583/entry"},{"label":"NCBI Gene 4254","url":"https://www.ncbi.nlm.nih.gov/gene/4254"},{"label":"Ensembl ENSG00000049130","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000049130"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["testicular"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KITLG","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6343","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6343","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P21583","url":"https://www.uniprot.org/uniprotkb/P21583/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000049130","url":"https://platform.opentargets.org/target/ENSG00000049130/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: testicular cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:6343","ensembl":"ENSG00000049130","uniprot":"P21583","entrez":"4254","biology":"Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, haematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signalling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. Location: Cell membrane; Cytoplasm; Cytoplasm, cytoskeleton; Cell projection, lamellipodium (UniProt). Locus 12q21.32 (HGNC).","whereFound":["Testicular germ cell tumours: Open Targets association 0.51 with testicular cancer (MONDO_0005447)"],"targetClass":"other","prevalence":[]},"route":"/targets/kitlg/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"testicular","kind":"cancer","name":"Testicular germ cell tumours","route":"/cancers/testicular/"}]}}