{"entity":{"id":"kivu-107","kind":"drug","name":"KIVU-107","aka":[],"tldr":"KIVU-107 is an experimental antibody-drug conjugate from Kivu Bioscience, in phase 1 trials for advanced solid tumours.","summary":"KIVU-107 is an antibody-drug conjugate (site-specific, GlycoConnect and HydraSpace) from Kivu Bioscience. An antibody-drug conjugate against PTK7, built with site-specific GlycoConnect and HydraSpace conjugation for a precise, stable drug-to-antibody ratio. Its furthest stage is phase 1, for advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Whether it works in people has not been established unless a trial below reports it.","status":"phase-1","asOf":"2026-11-03","links":[{"label":"Kivu Bioscience: kivubioscience.com","url":"https://kivubioscience.com/news/kivu-bioscience-to-present-preclinical-data-on-next-generation-adc-programs-at-aacr-annual-meeting-2026/"},{"label":"Kivu Bioscience: gimv.com","url":"https://www.gimv.com/en/node/4920"},{"label":"ClinicalTrials.gov: trials of KIVU-107","url":"https://clinicaltrials.gov/search?intr=KIVU-107"}],"tags":["pipeline","ctgov-ingest"],"related":[],"cancers":["metastatic-cancer"],"sections":[],"technologies":[],"targets":["ptk7"],"drugs":[],"companies":["kivu-bioscience"],"institutions":[],"pathways":[],"terms":[],"trials":["nct07229313"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"KIVU-107","modality":"Antibody-drug conjugate (site-specific, GlycoConnect and HydraSpace)","mechanism":"An antibody-drug conjugate against PTK7, built with site-specific GlycoConnect and HydraSpace conjugation for a precise, stable drug-to-antibody ratio.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/kivu-107/","neighbours":{"cancer":[{"id":"metastatic-cancer","kind":"cancer","name":"Metastatic cancer (cancer that has spread)","route":"/cancers/metastatic-cancer/"}],"target":[{"id":"ptk7","kind":"target","name":"PTK7","route":"/targets/ptk7/"}],"company":[{"id":"kivu-bioscience","kind":"company","name":"Kivu Bioscience","route":"/companies/kivu-bioscience/"}],"trial":[{"id":"nct07229313","kind":"trial","name":"A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors","route":"/trials/nct07229313/"}]}}