{"entity":{"id":"klc1","kind":"target","name":"KLC1","aka":["kinesin light chain 1","Kinesin light chain 1","KNS2A","hKLC1S","hKLC1N","hKLC1P","hKLC1G","hKLC1R","hKLC1J","hKLC1B","KNS2"],"tldr":"KLC1 (Kinesin light chain 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.\n\nOpen Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.76, genetic association 0.38).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6387","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6387"},{"label":"UniProt Q07866","url":"https://www.uniprot.org/uniprotkb/Q07866/entry"},{"label":"NCBI Gene 3831","url":"https://www.ncbi.nlm.nih.gov/gene/3831"},{"label":"Ensembl ENSG00000126214","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126214"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KLC1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:6387","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6387","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q07866","url":"https://www.uniprot.org/uniprotkb/Q07866/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000126214","url":"https://platform.opentargets.org/target/ENSG00000126214/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6387","ensembl":"ENSG00000126214","uniprot":"Q07866","entrez":"3831","biology":"Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Location: Cell projection, growth cone; Cytoplasmic vesicle; Cytoplasm, cytoskeleton (UniProt). Locus 14q32.33 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/klc1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}