{"entity":{"id":"klf2","kind":"target","name":"KLF2","aka":["KLF transcription factor 2","Krueppel-like factor 2"],"tldr":"KLF2 (Krueppel-like factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.66).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6347","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6347"},{"label":"UniProt Q9Y5W3","url":"https://www.uniprot.org/uniprotkb/Q9Y5W3/entry"},{"label":"NCBI Gene 10365","url":"https://www.ncbi.nlm.nih.gov/gene/10365"},{"label":"Ensembl ENSG00000127528","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000127528"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KLF2","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6347","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6347","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y5W3","url":"https://www.uniprot.org/uniprotkb/Q9Y5W3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KLF2","url":"https://civicdb.org/features/8253","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000127528","url":"https://platform.opentargets.org/target/ENSG00000127528/associations","note":"association with cancer (MONDO_0004992) 0.53;  (GraphQL API, CC0)"}],"hgnc":"HGNC:6347","ensembl":"ENSG00000127528","uniprot":"Q9Y5W3","entrez":"10365","biology":"Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements. Location: Nucleus (UniProt). Locus 19p13.11 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/klf2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}