{"entity":{"id":"klf5","kind":"target","name":"KLF5","aka":["KLF transcription factor 5","Krueppel-like factor 5","BTEB2"],"tldr":"KLF5 (Krueppel-like factor 5) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Cervical cancer, Colorectal cancer and 1 more.","summary":"Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes affected pathway 0.44, literature 0.99, genetic association 0.70, somatic mutation 0.80, animal model 0.46). IntOGen calls it a driver in 3 cohorts (2 activating, 1 loss-of-function), covering Bladder Urothelial Carcinoma, Cervical Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6349","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6349"},{"label":"UniProt Q13887","url":"https://www.uniprot.org/uniprotkb/Q13887/entry"},{"label":"NCBI Gene 688","url":"https://www.ncbi.nlm.nih.gov/gene/688"},{"label":"Ensembl ENSG00000102554","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000102554"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["urothelial","cervical","colorectal","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KLF5","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6349","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6349","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13887","url":"https://www.uniprot.org/uniprotkb/Q13887/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KLF5","url":"https://civicdb.org/features/634","note":"2 evidence items, 0 assertions, 2 variants; diseases:  (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000102554","url":"https://platform.opentargets.org/target/ENSG00000102554/associations","note":"association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen KLF5","url":"https://www.intogen.org/search?gene=KLF5","note":"driver in 3 cohorts (Act 2, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:6349","ensembl":"ENSG00000102554","uniprot":"Q13887","entrez":"688","biology":"Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Location: Nucleus (UniProt). Locus 13q22.1 (HGNC).","whereFound":["Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)","Cervical cancer: IntOGen driver in 1 cohort (CESC)","Colorectal cancer: Open Targets association 0.56 with colorectal cancer (MONDO_0005575)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/klf5/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}]}}