{"entity":{"id":"klhdc8b","kind":"target","name":"KLHDC8B","aka":["kelch domain containing 8B","Kelch domain-containing protein 8B","MGC35097"],"tldr":"KLHDC8B (Kelch domain-containing protein 8B) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Hodgkin lymphoma.","summary":"Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy.\n\n","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:28557","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28557"},{"label":"UniProt Q8IXV7","url":"https://www.uniprot.org/uniprotkb/Q8IXV7/entry"},{"label":"NCBI Gene 200942","url":"https://www.ncbi.nlm.nih.gov/gene/200942"},{"label":"Ensembl ENSG00000185909","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185909"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["hodgkin-lymphoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KLHDC8B","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:28557","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28557","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8IXV7","url":"https://www.uniprot.org/uniprotkb/Q8IXV7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000185909","url":"https://platform.opentargets.org/target/ENSG00000185909/associations","note":"per-cancer scores at or above 0.5: Hodgkins lymphoma 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:28557","ensembl":"ENSG00000185909","uniprot":"Q8IXV7","entrez":"200942","biology":"Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. Location: Cytoplasm; Midbody (UniProt). Locus 3p21.31 (HGNC).","whereFound":["Hodgkin lymphoma: Open Targets association 0.55 with Hodgkins lymphoma (MONDO_0004952)"],"targetClass":"other","prevalence":[]},"route":"/targets/klhdc8b/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"hodgkin-lymphoma","kind":"cancer","name":"Hodgkin lymphoma","route":"/cancers/hodgkin-lymphoma/"}]}}